I just ran across this cute little 3D game on the internet:
Remember to click the full-screen button in the bottom left, for a full experience. You will need the O3D plugin which will be included in Google Chrome, soon.
"C:\Documents and Settings\Username\Local Settings\Application Data\Google\Chrome\Application\chrome.exe" --app=http://blog.largeanimal.com/demo/
The game does not adapt to the window size and still shows some HTML stuff when not in full-screen mode, and it's also a bit slow to load compared to what we can expect in the future, but even in its current state, it makes it awfully old-fashioned to run setup programs or to use MSI files.